Nothing on this page should be interpreted as a prescription from a doctor. I am not a medical practitioner. I am only attempting to summarize information I have found from sources all over the internet in an easy-to-understand format.

Since the MTHFR mutation interferes with the breakdown of folic acid, the first line of defense is to supplement with a broken-down form of folic acid–optimized folate (l-methyl folate). Dr. Stephen Smith recommends Methyl-folate. He has created a flow chart of treatment for MTHFR that you could actually take to your doctor. It is a little complicated, but with some reading, it will make sense. You can view it by clicking here.

Dr. Neil Rawlins has posted a series of lectures on MTHFR. These are available at http://www.renewashoe.com/medical/. They are about seven years old and the quality isn’t fabulous, but the information is amazing. His son was sick for four years and nearly died before he was finally diagnosed with MTHFR. Like my family, every member of his family has one form of MTHFR or another. He made it his life’s work to understand this disorder. He wrote a very academic book about it entitled MTHFR Polymorphisms and Disease. It is out-of-print, but is available as a PDF for $99 at http://www.landesbioscience.com/books/iu/id/862/.

Here is a summary of Dr. Stephen’s chart regarding MTHFR treatment, hopefully translated into everyday English.

1) It is important to change one thing at a time and to take it slow. Because many people with MTHFR have a high toxicity level, adding in too much of anything too quickly can cause side effects that may be difficult to deal with and stress the liver.

2) There are many labs that it is helpful to have done so you know what your baselines are. Then, over time, you can retest and see how your body is responding to treatment.  Some of these labs are:
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MTHFR genetic test
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Liver Enzymes
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Homocysteine levels
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Ferritin
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Nitro Tyrosine (measures oxidative stress)
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Glutathione
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Methyl B-12 (may be high, but the body can’t use)
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Heavy Metals
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Urine Organic Acids
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Toxin Screen
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Amino Acids
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Porphryns

3) If there are gastro-intestinal issues, the gut must be repaired first before embarking on a detoxification or chelation protocol. If constipation exists, the toxins are stuck in the body, so elimination must be established and regulating before drawing more toxins out of the body. Gastro-intestinal problems may exist because of leaky gut conditions (tiny holes in the intestinal walls); gluten intolerance; other food sensitivities; parasites; candida overgrowth; fungal infections, and other bacterial/viral infections.

4) Treatment of MTHFR includes supplementing the things your body can’t make or use effectively. These will vary some from person to person. Each person in my family has a slightly different combination based on our individual needs. Supplements will include an active form of folate (NOT folic acid) and most likely methyl B-12. Other supplements may include:

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DMG or TMG (methyl donors)
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Fatty Acids (Fish/Krill Oil, flaxseed)
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Zinc
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Magnesium
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Selenium
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Vitamin E
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Vitamin C
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Amino Acids
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B-Complex (particularly B-6)
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Herbal Liver Detoxifier
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N-Acetyl Cysteine (precursor to glutathione)
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Glutathione
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5-HTP
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Biopterin

5) Detoxification is key to allow the system to get back to a healthy state. This should be done gently and slowly, according to many doctors, to avoid a toxic overload. This can be done through herbal cleanses, homeopathic remedies, clay baths, ionic foot baths, epsom salt baths, and more.

6) Because individuals with MTHFR don’t detoxify well, you will need to be mindful about staying away from toxic ingredients in your food, your home, and your environment. In food, this includes any food sensitivities you’ve identified (commonly gluten and dairy), nitrates, food dyes, preservatives and high fructose corn syrup. Buy organic and grass-fed meats if you can. Use natural pest control and change your cleaning products to organic natural cleaners. Take a second look at your shampoos, deodorants, toothpaste, and make-up. Chances are you are taking in a huge amount of toxins from these. This takes time, so be kind to yourself and do a bit at a time.

7) Re-evaluate, adjust, and move forward. This is a journey and will take time. It is a bit like unpeeling an onion. You get off one layer and then something else will pop up its ugly head. Every step forward is a step forward.
Treatment for MTHFR